rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Intrinsically Disordered Proteins
  name:
    name part: Uversky, Vladimir N.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 61 p. 13 illus., 10 illus. in color. online resource.
  abstract: In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
  table of contents: Introducing the phenomenon of protein intrinsic disorder -- Peculiar amino acid sequences of soluble IDPs -- Natural abundance of IDPs/IDPRs -- Wavy evolution of intrinsic disorder: Reinventing the wheel -- Structural heterogeneity of IDPs: When almost everything is possible -- Typical functions of IDPs and IDPRs -- Binding promiscuity and multitude of the disorder-based binding modes -- IDPs/IDPRs in human diseases -- IDPs as potential drug targets -- Concluding remarks: Intrinsic disorder as a universal tool for solving protein mysteries and riddles.
  note: by Vladimir N. Uversky.
  subject:
    topic: Life sciences
  subject:
    topic: Medicinal chemistry
  subject:
    topic: Biochemistry
  subject:
    topic: Proteins
  subject:
    topic: Life Sciences
  subject:
    topic: Protein Structure
  subject:
    topic: Medicinal Chemistry
  subject:
    topic: Biochemistry, general
  classification: QD431-431.7
  classification: 572.633
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: SpringerBriefs in Molecular Science
  identifier: 9783319089218
  identifier: http://dx.doi.org/10.1007/978-3-319-08921-8
  record info:
    record creation date: 140805
    record change date: 20151029231458.0
    record identifier: 978-3-319-08921-8