rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: DNA Replication Control in Microbial Cell Factories
  name:
    name part: Glinkowska, Monika.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Boss, Lidia.
    role:
      role term: author.
  name:
    name part: Wegrzyn, Grzegorz.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: V, 50 p. 4 illus. in color. online resource.
  abstract: This work describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control of activity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition, similarities of the mechanisms of regulation of DNA replication operating in prokaryotic and eukaryotic cells are identified, and implications for understanding more complex processes, like carcinogenesis are suggested. Studies of recent years provided evidence that regulation of DNA replication in bacteria is more complex than previously anticipated. Multiple layers of control seem to ensure coordination of this process with the increase of cellular mass and the division cycle. Metabolic processes and membrane composition may serve as points where integration of genome replication with growth conditions occurs. It is also likely that coupling of DNA synthesis with cellular metabolism may involve interactions of replication proteins with other macromolecular complexes, responsible for various cellular processes. Thus, the exact set of factors participating in triggering the replication initiation may differ depending on growth conditions. Therefore, understanding the regulation of DNA duplication requires placing this process in the context of the current knowledge on bacterial metabolism, as well as cellular and chromosomal structure. Moreover, in both Escherichia coli and eukaryotic cells, replication initiator proteins were shown to play other roles in addition to driving the assembly of replication complexes, which constitutes another, yet not sufficiently understood, layer of coordinating DNA replication with the cell cycle.
  table of contents: Introduction.- Coordinating duplication of genetic material with cell growth – current views and old questions.- Structural organization of cellular processes and the regulation of cell cycle -- The link between metabolism and DNA replication -- Transcriptional activation – the unsolved problem -- Activity of DnaA is inhibited by components of translation machinery -- Nucleoid-associated proteins modulate activity of the DnaA initiator -- Interaction of DnaA with acidic components of fluid cellular membrane regulates its nucleotide-bound status and binding to oriC -- Influence of DNA replication on cell structure and function -- Conclusions.
  note: by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn.
  subject:
    topic: Life sciences
  subject:
    topic: Microbiology
  subject:
    topic: Cell biology
  subject:
    topic: Life Sciences
  subject:
    topic: Microbiology
  subject:
    topic: Applied Microbiology
  subject:
    topic: Cell Biology
  classification: QR1-502
  classification: 579
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: SpringerBriefs in Microbiology
  identifier: 9783319105338
  identifier: http://dx.doi.org/10.1007/978-3-319-10533-8
  record info:
    record creation date: 140923
    record change date: 20151030031401.0
    record identifier: 978-3-319-10533-8