rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Neuroanatomy and Pathology of Sporadic Alzheimer's Disease
  name:
    name part: Braak, Heiko.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Del Tredici, Kelly.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XI, 162 p. 48 illus., 44 illus. in color. online resource.
  abstract: As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail.
  table of contents: Prologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations. .
  note: by Heiko Braak, Kelly Del Tredici.
  subject:
    topic: Medicine
  subject:
    topic: Neurosciences
  subject:
    topic: Geriatrics
  subject:
    topic: Pathology
  subject:
    topic: Biomedicine
  subject:
    topic: Neurosciences
  subject:
    topic: Pathology
  subject:
    topic: Geriatrics/Gerontology
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Advances in Anatomy, Embryology and Cell Biology, 215
  identifier: 9783319126791
  identifier: http://dx.doi.org/10.1007/978-3-319-12679-1
  record info:
    record creation date: 141211
    record change date: 20151201031053.0
    record identifier: 978-3-319-12679-1