rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Resistance to Photodynamic Therapy in Cancer
  name:
    name part: Rapozzi, Valentina.
    role:
      role term: editor.
  name:
    name part: Jori, Giulio.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 248 p. 48 illus., 36 illus. in color. online resource.
  abstract: This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.
  table of contents: Basic and Clinical Aspects of photodynamic Therapy -- Mechanisms of Resistance to Photodynamic Therapy -- Tumor Vascular Microenvironment Determines responsiveness to Photodynamic Therapy -- Autophagy Pathways Activated in Response to PDT Contribute to Cell Resistance Against ROS Damage -- Methods to isolate the Resistant Cells to Photodynamic Therapy -- GRP78-Targeting Subtilase Cytotoxin Sensitizes Cancer Cells to Photodynamic Therapy -- Optimization of Photodynamic Therapy Response by Survivin Gene Knockdown in Human Metastatic Breast Cancer -- Cellular Targets and Molecular Responses Associated with Photodynamic Therapy -- The Use of Nanoparticle-Delivered Photosensitizers Can Overcome the Development of Resistance to PDT in Tumors -- Mechanisms of tumor cells resistance to ALA/PDT -- Overcoming the Resistance of Meolanoma to Photodynamic Therapy.
  note: edited by Valentina Rapozzi, Giulio Jori.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Drug resistance
  subject:
    topic: Molecular biology
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Drug Resistance
  subject:
    topic: Molecular Medicine
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Resistance to Targeted Anti-Cancer Therapeutics, 5
  identifier: 9783319127309
  identifier: http://dx.doi.org/10.1007/978-3-319-12730-9
  record info:
    record creation date: 141211
    record change date: 20151103130039.0
    record identifier: 978-3-319-12730-9