rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Branching Process Models of Cancer
  name:
    name part: Durrett, Richard.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VII, 63 p. 6 illus., 2 illus. in color. online resource.
  abstract: This volume develops results on continuous time branching processes and applies them to study rate of tumor growth, extending classic work on the Luria-Delbruck distribution. As a consequence, the authors calculate the probability that mutations that confer resistance to treatment are present at detection and quantify the extent of tumor heterogeneity. As applications, the authors evaluate ovarian cancer screening strategies and give rigorous proofs for results of Heano and Michor concerning tumor metastasis. These notes should be accessible to students who are familiar with Poisson processes and continuous time. Richard Durrett is mathematics professor at Duke University, USA. He is the author of 8 books, over 200 journal articles, and has supervised more than 40 Ph.D. students. Most of his current research concerns the applications of probability to biology: ecology, genetics, and most recently cancer.
  table of contents: Multistage Theory of Cancer -- Mathematical Overview -- Branching Process Results -- Time for Z_0 to Reach Size M -- Time Until the First Type 1 -- Mutation Before Detection? -- Accumulation of Neutral Mutations -- Properties of the Gamma Function -- Growth of Z_1(t) -- Movements of Z_1(t) -- Luria-Delbruck Distributions -- Number of Type 1's at Time T_M -- Gwoth of Z_k(t) -- Transitions Between Waves -- Time to the First Type \tau_k, k \ge 2 -- Application: Metastasis -- Application: Ovarian Cancer -- Application: Intratumor Heterogeneity.
  note: by Richard Durrett.
  subject:
    topic: Mathematics
  subject:
    topic: Cancer research
  subject:
    topic: Probabilities
  subject:
    topic: Biomathematics
  subject:
    topic: Mathematics
  subject:
    topic: Probability Theory and Stochastic Processes
  subject:
    topic: Mathematical and Computational Biology
  subject:
    topic: Cancer Research
  classification: QA273.A1-274.9
  classification: QA274-274.9
  classification: 519.2
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Mathematical Biosciences Institute Lecture Series ; 1.1
  identifier: 9783319160658
  identifier: http://dx.doi.org/10.1007/978-3-319-16065-8
  record info:
    record creation date: 150620
    record change date: 20151123144347.0
    record identifier: 978-3-319-16065-8