rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Histone Recognition
  name:
    name part: Zhou, Ming-Ming.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 282 p. 69 illus., 51 illus. in color. online resource.
  abstract: This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.
  table of contents: The Bromodomain as the Acetyl-Lysine Binding Domain in Gene Transcription -- PHD Fingers as Histone Readers -- Methyl-Lysine Recognition by the Royal Family Modules: Chromo, Tudor, MBT, Chromo Barrel, and PWWP Domains -- Histone Recognition by WD40 Proteins -- Methyl-Lys Recognition by Ankyrin Repeat Proteins -- Methyl-Arginine Recognition by Tudor Domains -- Histone Recognition by Tandem Modules and Modulation by Multiple PTMs -- Genome-Wide Profiling of Molecular Recognition of Histone PTMs -- BET Bromodomain Inhibition as a Therapeutic Approach in Hematological Malignancies -- Anti-Inflammatory Effects of BET Protein Inhibition Through Modulation of Gene Transcription -- Activating Latent HIV by Inhibiting Bromodomain Proteins -- Small Molecule Modulation of Methyl-Lysine Mediated Interactions.
  note: edited by Ming-Ming Zhou.
  subject:
    topic: Medicine
  subject:
    topic: Gene expression
  subject:
    topic: Medical genetics
  subject:
    topic: Proteins
  subject:
    topic: Posttranslational modification
  subject:
    topic: Biomedicine
  subject:
    topic: Gene Expression
  subject:
    topic: Posttranslational Modification
  subject:
    topic: Protein-Ligand Interactions
  subject:
    topic: Gene Function
  classification: QP110.G45
  classification: 611.01816
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783319181028
  identifier: http://dx.doi.org/10.1007/978-3-319-18102-8
  record info:
    record creation date: 150529
    record change date: 20151204182427.0
    record identifier: 978-3-319-18102-8