rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Proteases in Apoptosis: Pathways, Protocols and Translational Advances
  name:
    name part: Bose, Kakoli.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2015
    edition: 1st ed. 2015.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 245 p. 51 illus., 50 illus. in color. online resource.
  abstract: This book provides a comprehensive overview of the proteases involved in programmed cell death. It presents a focused yet extensive discussion on proteolytic enzymes such as caspases, HtrAs, granzymes, calpains and cathepsins as well as laboratory protocols related to enzymology and apoptosis. Mouse model systems and non-invasive imaging techniques in apoptosis-related diseases such as cancer and neurodegeneration are also covered in this book. While slowly unravelling the complexities of apoptosis in chapter one, the next three chapters individually elaborate on different classes of proteases that play key roles in the initiation, progression and execution of programmed cell death. The last two chapters complete this discussion by describing different laboratory methodologies and therapeutic advances involving apoptotic proteases. Protocols portraying in vitro and ex vivo colorimetric and fluorescence-based enzyme kinetic studies as well as cell death assays are explained in the fifth chapter. Preclinical in vivo models and non-invasive imaging in apoptosis to understand the complexities of disease progression and their contribution toward therapeutics are recounted in the last chapter. The book spans topics related to both fundamental and applied biology. It would therefore be equally appealing and informative to scientists working in the field of apoptosis and those who are investigating mechanisms of proteases and enzymes in general. The protocols would certainly benefit both graduate and undergraduate students working in the related fields and provide useful leads for drug design to translational biologists involved in neurodegeneration and cancer research.
  table of contents: Apoptosis: Pathways, Molecules and Beyond -- Caspases - key players in apoptosis -- Calpains and Granzymes: non-caspase proteases in cell death -- Cathepsins and HtrAs - multitasking proteases in programmed cell death -- Proteases in Apoptosis: Protocols and Methods -- Preclinical Animal Model and Non-invasive Imaging in Apoptosis.
  note: edited by Kakoli Bose.
  subject:
    topic: Life sciences
  subject:
    topic: Medical biochemistry
  subject:
    topic: Apoptosis
  subject:
    topic: Life Sciences
  subject:
    topic: Apoptosis
  subject:
    topic: Biomedicine general
  subject:
    topic: Medical Biochemistry
  classification: QH573-671
  classification: 571.936
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783319194974
  identifier: http://dx.doi.org/10.1007/978-3-319-19497-4
  record info:
    record creation date: 150806
    record change date: 20151128081327.0
    record identifier: 978-3-319-19497-4