rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: Adenosinergic System
    sub title: A Non-Dopaminergic Target in Parkinson’s Disease
  name:
    name part: Morelli, Micaela.
    role:
      role term: editor.
  name:
    name part: Simola, Nicola.
    role:
      role term: editor.
  name:
    name part: Wardas, Jadwiga.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2015
    edition: 1st ed. 2015.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XII, 337 p. 41 illus., 31 illus. in color. online resource.
  abstract: Adenosine A2A receptor antagonists have shown great promise in the treatment of Parkinson's Disease and alleviation of symptoms. This book addresses various aspects of this class of drugs from their chemical development to their clinical use. Among the many insightful chapters contained in this book, there are three unique reviews that have not previously been published in any format: (1) a history of istradefylline, the first A2A antagonist approved for treatment of Parkinson's Disease, (2) an overview of neuroimaging studies in human health and disease, and (3) a study of urate as a possible biomarker and neuroprotectant.
  table of contents: Adenosine A2A receptors: localization and function -- Allosteric Mechanisms in the adenosine A2A-dopamine D2 receptor heteromer -- Adenosine A2A receptor antagonists in drug development -- Adenosine A2A Receptors and Neurotrophic Factors: Relevance for Parkinson's Disease -- Role of adenosine A2A receptors in the control of neuroinflammation – relevance for Parkinson’s disease -- Purines in Parkinson's: Adenosine A2A receptors and urate as targets for neuroprotection -- Adenosine A2A receptor antagonists as drugs for symptomatic control of Parkinson’s disease in preclinical studies -- Dopamine/adenosine interactions related to tremor in animal models of Parkinsonism -- Adenosine A2A receptor antagonists in L-DOPA-induced motor fluctuations -- Adenosine A2A receptor-mediated control of non-motor functions in Parkinson’s disease -- Imaging Studies with A2A Receptor Antagonists -- Caffeine and neuroprotection in Parkinson's disease -- The story of istradefylline – the first approved A2A antagonist for the treatment of Parkinson’s disease -- Adenosinergic Receptor Antagonists: Clinical Experience in Parkinson's Disease -- Adenosinergic regulation of sleep-wake behavior in the basal ganglia.
  note: edited by Micaela Morelli, Nicola Simola, Jadwiga Wardas.
  subject:
    topic: Medicine
  subject:
    topic: Neurosciences
  subject:
    topic: Neurology
  subject:
    topic: Biomedicine
  subject:
    topic: Neurosciences
  subject:
    topic: Neurology
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Current Topics in Neurotoxicity, 10
  identifier: 9783319202730
  identifier: http://dx.doi.org/10.1007/978-3-319-20273-0
  record info:
    record creation date: 150907
    record change date: 20170127141639.0
    record identifier: 978-3-319-20273-0