rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Sample Size Determination in Clinical Trials with Multiple Endpoints
  name:
    name part: Sozu, Takashi.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Sugimoto, Tomoyuki.
    role:
      role term: author.
  name:
    name part: Hamasaki, Toshimitsu.
    role:
      role term: author.
  name:
    name part: Evans, Scott R.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2015
    edition: 1st ed. 2015.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VI, 95 p. 17 illus. online resource.
  abstract: This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area. The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed; if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clinical trials where the alternative hypothesis is that there are effects on ALL endpoints are discussed in detail. The book also brieﬂy examines trials designed with an alternative hypothesis of an effect on AT LEAST ONE endpoint with a prespeciﬁed non-ordering of endpoints. .
  table of contents: 1.Introduction -- 2.Continuous Co-primary Endpoints -- 3.Binary Co-primary Endpoints -- 4.Convenient Sample Size Formula -- 5.Continuous Primary Endpoints -- 6. Further Developments -- A.Sample Size Calculation Using other Contrasts for Binary Endpoints -- B.Empirical Power for Sample Size Calculation for Binary Co-primary Endpoints -- C.Numerical Tables for Ck in the Convenient Sample Size Formula for the Three Co-primary Continuous Endpoints Cace -- D.Software Programs for Sample Size Calculation for Continuous Co-primary Endpoints -- References.
  note: by Takashi Sozu, Tomoyuki Sugimoto, Toshimitsu Hamasaki, Scott R. Evans.
  subject:
    topic: Statistics
  subject:
    topic: Biostatistics
  subject:
    topic: Statistics
  subject:
    topic: Statistical Theory and Methods
  subject:
    topic: Statistics for Life Sciences, Medicine, Health Sciences
  subject:
    topic: Biostatistics
  classification: QA276-280
  classification: 519.5
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: SpringerBriefs in Statistics
  identifier: 9783319220055
  identifier: http://dx.doi.org/10.1007/978-3-319-22005-5
  record info:
    record creation date: 150820
    record change date: 20170313151419.0
    record identifier: 978-3-319-22005-5