rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Organic Cation Transporters
    sub title: Integration of Physiology, Pathology, and Pharmacology
  name:
    name part: Ciarimboli, Giuliano.
    role:
      role term: editor.
  name:
    name part: Gautron, Sophie.
    role:
      role term: editor.
  name:
    name part: Schlatter, Eberhard.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2016
    edition: 1st ed. 2016.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 264 p. 34 illus., 14 illus. in color. online resource.
  abstract: This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.
  table of contents: Introduction to the cellular transport of organic cations -- Functional properties of organic cation transporter OCT1, binding of substrates and inhibitors, and presumed transport mechanism -- Pharmacological and toxicological significance of the organic cation transporters OCT and MATE: Drug disposition, interaction and toxicity -- Genetic variability in organic cation transporters: pathophysiological manifestations and consequences for drug pharmacokinetics and efficacy -- Physiological and pathological regulation of transporters for organic cations -- Endocrine and metabolic regulation of transporters for organic cations -- Organic cation transporters (OCTs) as modulators of behavior and mood -- Organic cation transporters as modulators of neurodegeneration and neuroprotection -- Translational relevance of animal models for the study of organic cation transporter function -- Role of transporters for organic cations in plants for environmental cycling of pharmaceutical residues.
  note: edited by Giuliano Ciarimboli, Sophie Gautron, Eberhard Schlatter.
  subject:
    topic: Medicine
  subject:
    topic: Human physiology
  subject:
    topic: Pharmacology
  subject:
    topic: Pathology
  subject:
    topic: Biomedicine
  subject:
    topic: Human Physiology
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Pathology
  classification: QP34-38
  classification: 612
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783319237930
  identifier: http://dx.doi.org/10.1007/978-3-319-23793-0
  record info:
    record creation date: 151217
    record change date: 20151217102541.0
    record identifier: 978-3-319-23793-0