rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Patho-Epigenetics of Infectious Disease
  name:
    name part: Minarovits, Janos.
    role:
      role term: editor.
  name:
    name part: Niller, Hans Helmut.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2016
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 137 p. 8 illus. in color. online resource.
  abstract: Epigenetic modification of cellular genomes is a fascinating means of regulating tissue- and cell type-specific gene expression in all developmental stages of the life of an organism. Carefully orchestrated processes, such as DNA methylation and a plenitude of specific histone modifications secure the faithful transmission of gene expression patterns to progeny cells. Upon chronic infection, the epigenetic cellular balance can become disrupted and, in the long run, through the epigenetic reprogramming of host cell genomes, contribute to the malignant conversion of formerly healthy cells, in many cases preceded by the establishment of an epigenetic field of cancerization. The present volume undertakes to highlight the interactions of infectious pathogens and their effector molecules with the epigenetic regulatory machinery of the cell. Clearly, the recent take-off of epigenetics research did not leave Research on Infectious Diseases and Infection-Associated Cancer untouched. This resulted in a great many of clinically relevant data on understanding the molecular mechanisms of chronic infectious disease. Infectious pathogen- and disease-specific epigenetic alterations are already being used for the early detection of malignant disease and for the prediction of chemotherapy resistance or response to treatment.
  note: edited by Janos Minarovits, Hans Helmut Niller.
  subject:
    topic: Life sciences
  subject:
    topic: Medical microbiology
  subject:
    topic: Molecular biology
  subject:
    topic: Virology
  subject:
    topic: Infectious diseases
  subject:
    topic: Microbial genetics
  subject:
    topic: Microbial genomics
  subject:
    topic: Life Sciences
  subject:
    topic: Microbial Genetics and Genomics
  subject:
    topic: Infectious Diseases
  subject:
    topic: Molecular Medicine
  subject:
    topic: Virology
  subject:
    topic: Medical Microbiology
  classification: QH434
  classification: 579.135
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Advances in Experimental Medicine and Biology, 879
  identifier: 9783319247380
  identifier: http://dx.doi.org/10.1007/978-3-319-24738-0
  record info:
    record creation date: 151211
    record change date: 20170718130938.0
    record identifier: 978-3-319-24738-0