rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Towards a New Neuromorphology
  name:
    name part: Nieuwenhuys, Rudolf.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Puelles, Luis.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2016
    edition: 1st ed. 2016.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 344 p. 133 illus., 95 illus. in color. online resource.
  abstract: This book demonstrates that the systematic study of gene expression patterns in embryonic and adult brains, in combination with selected data from earlier studies, can pave the way for a new neuromorphology, the most salient features of which may be summarized as follows: (1) Causal analysis of molecular patterning at neural plate and early neural tube stages has shown that the CNS is essentially organized into transverse neural segments or neuromeres and longitudinal zones which follow the curved axis of the brain. (2) The FMUs initially represent thin neuroepithelial fields; in the course of further development they are transformed into three-dimensional radial units, extending from the ventricular surface to the meningeal surface of the brain. (3) The principal histogenetic processes, including cellular proliferation, cell migration and differentiation, essentially take place within the confines of these radial units, controlled by characteristic sets of developmental regulatory genes. (4) Although most developing neurons migrate radially and settle within their own FMU, at many locations neuroblasts leave the FMU where they were produced and migrate tangentially to other nearby or remote territories, colonizing parts of foreign FMUs. (5) Many structural complexes in the adult brain, including the cerebral and cerebellar cortices, are the products of radial and tangential intermingling of migrated cell contingents. (6) By using appropriate molecular markers, all neuron types in the adult CNS can be traced back to a specific progenitor zone within a specific FMU, and the progeny of any FMU can be traced to their final positions with the help of selective labeling approaches. (7) Early outgrowing axons form bundles, which tend to pass close to the border zones of the radial units. By means of their molecularly diversely tuned growth cones, these extending axons decide how to behave at each boundary they encounter, sometimes even reorienting at right angles. Collect…
  table of contents: 1. From classic to modern neuromorphology, an introductory overview -- 2. The neural plate -- 3. From neural plate to neural tube -- 4. The neural tube -- 5. The axis of the brain, its flexures and correlates -- 6. The (complex) rostral part of the brain -- Summary -- 7. The natural coordinate system of the CNS -- 8. The fundamental morphological units (FMUs) of the CNS -- 9. The structural pattern, ’Bauplan’ or ‘blueprint’ of the CNS -- 10. The development of grisea -- 11. The ‘wiring’ of the brain -- 12. General summary, conclusions and perspective -- References -- Index.
  note: by Rudolf Nieuwenhuys, Luis Puelles.
  subject:
    topic: Medicine
  subject:
    topic: Neurosciences
  subject:
    topic: Neurology
  subject:
    topic: Neurobiology
  subject:
    topic: Biomedicine
  subject:
    topic: Neurosciences
  subject:
    topic: Neurobiology
  subject:
    topic: Neurology
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783319256931
  identifier: http://dx.doi.org/10.1007/978-3-319-25693-1
  record info:
    record creation date: 151228
    record change date: 20160418142036.0
    record identifier: 978-3-319-25693-1