rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Transgenesis and Secondary Metabolism
  name:
    name part: Jha, Sumita.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2017
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: 108 illus., 65 illus. in color. eReference. online resource.
  abstract: This handbook provides comprehensive reference information on the efficient production of secondary metabolites from plants by transgenesis and other genetic manipulation strategies. It reviews and summarizes selected important case studies in genetic methods applied to enhance the production of a given metabolite or a group of related or derived compounds. Readers will find reference information on a multitude of techniques and methods, including traditional breeding and screening; over-expression of genes encoding key enzymes; functional genomics approaches; metabolic engineering of the relevant biosynthetic pathways; indirect genetic approaches to improve metabolite production, including Agrobacterium mediated transformations. Furthermore, combinatorial biochemistry approaches to engineer secondary metabolic pathways are summarized, which can offer access to new structures or to the design of novel compounds. Since many commercially valuable substances are still extracted from plants, being largely inaccessible to efficient modern laboratory synthesis methods, this book provides a valuable resource of information for biotechnological approaches that can help to find alternative and more efficient methods for the production of natural secondary metabolites. Thus adjusted production methods, with the help of tailored plant systems, can potentially help to release the stress on plants, which are currently suffering from extensive human harvesting, and to conserve global biodiversity. Readers will find comprehensive reference information on plant genetic manipulation toward more efficient synthesis, accumulation and production of target secondary metabolites. The handbook will appeal to researchers and professionals, but also graduate students and scholars working in the fields of biotechnology, genetic engineering, medicinal plant research, pharmacy, and phytochemistry.
  table of contents: Part I General Aspects of Transgenesis and Secondary Metabolism: DNA Transfer to Plants by Agrobacterium rhizogenes: A Model for Genetic Communication Between Species and Biospheres -- Secondary Metabolism and the Rationale for Systems Manipulation -- Plant Cell Cultures as Producers of Secondary Metabolites: Podophyllum Lignans as a Model -- Secondary Metabolite Production in Transformed Cultures -- Antimalarial Compound Synthesis from Transgenic Cultures -- Evaluation of Agrobacterium tumefaciens Usefulness for the Transformation of Sage (Salvia Officinalis L.) -- Ruta Graveolens: Phytochemistry, Pharmacology and Biotechnology -- Secondary Metabolite Profile of Transgenic Centaury (Centaurium erythraea Rafn.) Plants, Potential Producers of Anticancer Compounds -- Syzygium cumini (L.) Skeels: Cardiometabolic Properties and Potential Tissue Culture-Based Improvement of Secondary Metabolites Production -- Part II Hairy roots and Secondary Metabolism: Secondary Products from Plant Cell Cultures – Early Experiences with Agrobacterium rhizogenes-transformed Hairy Roots -- Secondary Metabolite Production in Transgenic Hairy Root Cultures of Cucurbits -- “Hairy Root” Technology: An Emerging Arena for Heterologous Expression of Biosynthetic Pathway Genes in Medicinal Plants -- Agrobacterium rhizogenes -Mediated Transformation in Medicinal Plants: Genetic Stability in Long Term Culture -- Biotransformation Through Hairy Roots: Perspectives, Outcomes, and Major Challenges -- Part III Metabolic Engineering: Metabolic Engineering of Lignan Biosynthesis Pathways for the Production of Transgenic Plant-Based Foods -- The Elucidation and Metabolic Engineering of Terpenoid Indole Alkaloid Pathway in Catharanthus roseus Hairy Roots -- Pathway Modulation of Medicinal and Aromatic Plants Through Metabolic Engineering Using Agrobacterium tumefaciens -- Metabolic Engineering for Improving the Production of Taxol -- Metabolic Engineering of Phenyl Propanoids in Plants -- Part IV Metaboli…
  note: edited by Sumita Jha.
  subject:
    topic: Chemistry
  subject:
    topic: Pharmacy
  subject:
    topic: Genetic engineering
  subject:
    topic: Bioorganic chemistry
  subject:
    topic: Plant biochemistry
  subject:
    topic: Metabolism
  subject:
    topic: Plant genetics
  subject:
    topic: Chemistry
  subject:
    topic: Genetic Engineering
  subject:
    topic: Plant Genetics & Genomics
  subject:
    topic: Plant Biochemistry
  subject:
    topic: Metabolomics
  subject:
    topic: Bioorganic Chemistry
  subject:
    topic: Pharmacy
  classification: TP248.6
  classification: 660.65
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Reference Series in Phytochemistry
  identifier: 9783319286693
  identifier: http://dx.doi.org/10.1007/978-3-319-28669-3
  record info:
    record creation date: 170508
    record change date: 20170508180201.0
    record identifier: 978-3-319-28669-3