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Vascular Ion Channels in Physiology and Disease
XVII, 431 p. 103 illus., 75 illus. in color. online resource.
Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.
Foreword -- Endothelial cell ion channel expression and function in arterioles and resistance arteries -- Contribution and Regulation of Calcium channels in Endothelial Cells -- Mitochondrial depolarization in endothelial and other vascular cells and their role in the regulation of cerebral vascular tone -- Ion channels in Hypertension and Control of Blood Flow: Electrical conduction along endothelium of resistance arteries -- Ca2+/calmodulin-gated small- and intermediate-conductance KCa channels in cardiovascular regulation: Targets for novel pharmacological treatments -- Regional Variation in Arterial Myogenic Responsiveness - Links to Potassium Channel Diversity/Function -- Ion Channel Trafficking and Control of Arterial Contractility -- Abnormalities of Vascular Ion Channels during Hypertension -- Kv7 Potassium Channels as Therapeutic Targets in Cerebral Vasospasm -- Lysosomal Transient Receptor Potential Mucolipin (TRPML) Channels in Vascular Regulation and Diseases -- Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth Muscle -- Role of mechanosensitive TRP channels in Abnormal Vasculature of Tumors -- TRPC and Orai channels in store-operated calcium entry and vascular remodeling -- Smooth muscle cell ion channels in pulmonary arterial hypertension: pathogenic role in pulmonary vasoconstriction and vascular remodeling -- Physiological roles and cholesterol sensitivity of endothelial inwardly-rectifying K+ channels: specific cholesterol-protein interactions through non annular binding sites -- Membrane lipids and regulation of smooth muscle ion channels -- Transient receptor potential channels in metabolic syndrome-induced coronary artery disease -- Mitochondrial ion channels in metabolic disease -- Index.
edited by Irena Levitan, PhD, Alex M. Dopico, MD, PhD.