rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors
  name:
    name part: Oberleitner, Maximilian.
    role:
      role term: creator
    role:
      role term: author.
    role:
      role term: aut
    role:
      role term: http://id.loc.gov/vocabulary/relators/aut
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2018
    edition: 1st ed. 2018.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXVI, 370 p. 138 illus., 122 illus. in color. online resource.
  abstract: This thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research. The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design principles and elucidates the boundary conditions of the new sensors.
  table of contents: Introduction -- Objectives -- Methods & Instrumentation -- MQCM: Multiple Cytomechanic Sensing -- QCM-ECIS: Combined Viscoelastic and Dielectric Sensing of Cells -- QCM-OCS: Optochemical Sensing of Temperature and pO2 in the Cell Surface Junction -- Summary -- Appendix.
  note: by Maximilian Oberleitner.
  subject:
    topic: Analytical chemistry
  subject:
    topic: Nanochemistry
  subject:
    topic: Laboratory medicine
  subject:
    topic: Cell culture
  subject:
    topic: Biophysics
  subject:
    topic: Biological physics
  subject:
    topic: Analytical Chemistry
  subject:
    topic: Nanochemistry
  subject:
    topic: Laboratory Medicine
  subject:
    topic: Cell Culture
  subject:
    topic: Biological and Medical Physics, Biophysics
  classification: QD71-142
  classification: 543
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Springer Theses, Recognizing Outstanding Ph.D. Research
  identifier: 9783319453842
  identifier: https://doi.org/10.1007/978-3-319-45384-2
  record info:
    record creation date: 170927
    record change date: 20191024021229.0
    record identifier: 978-3-319-45384-2