rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: GABAB Receptor
  name:
    name part: Colombo, Giancarlo.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2016
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XX, 385 p. 64 illus., 19 illus. in color. online resource.
  abstract: An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.
  table of contents: 1. Historical Perspectives on the GABAB Receptor -- Section 1. Chemistry -- 2. Chemistry of GABAB Receptor Ligands: Focus on Agonists and Antagonists -- 3. Chemistry of GABAB Receptor Ligands: Focus on Positive Allosteric Modulators -- Section 2. Molecular Biology, Biochemistry, & Physiology -- 4. Molecular Structure and Trafficking of the GABAB Receptor -- 5. Distribution and Localization of the GABAB Receptor -- 6. Activation Mechanism and Allosteric Properties of the GABAB Receptor -- 7. Modulation of Neurotransmission by the GABAB Receptor -- 8. GABAB Receptor Functions In The Mesolimbic Dopamine System -- Section 3. Pharmacology -- 9. Drug Discrimination Studies for Investigations on the Mechanisms of Action of GABAB Receptor Ligands -- 10. Targeting the GABAB Receptor for the Treatment of Epilepsy -- 11. Targeting the GABAB Receptor for the Treatment of Pain -- 12. Targeting the GABAB Receptor for the Treatment of Psychiatric Disorders -- 13. Targeting the GABAB Receptor for the Treatment of Fragile X Syndrome and Autism Spectrum Disorders -- 14. Targeting the GABAB Receptor for the Treatment of Substance Use Disorder -- 15. Targeting the GABAB Receptor for the Treatment of Alcohol Use Disorder -- 16. Targeting GABAB Receptors for the Treatment of Gastroesophageal Reflux Disease and Chronic Cough -- 17. Baclofen: Therapeutic Use and Potential of the Prototypic GABAB Receptor Agonist -- 18. Allosteric Modulators: The New Generation of GABAB Receptor Ligands -- 19. GABAB Receptor Antagonists as Cognition Enhancers.
  note: edited by Giancarlo Colombo.
  subject:
    topic: Medicine
  subject:
    topic: Neurosciences
  subject:
    topic: Neurology
  subject:
    topic: Biomedicine
  subject:
    topic: Neurosciences
  subject:
    topic: Neurology
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: The Receptors ; 29
  identifier: 9783319460444
  identifier: http://dx.doi.org/10.1007/978-3-319-46044-4
  record info:
    record creation date: 161219
    record change date: 20161219154554.0
    record identifier: 978-3-319-46044-4