rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Structural Bioinformatics Tools for Drug Design
    sub title: Extraction of Biologically Relevant Information from Structural Databases
  name:
    name part: Koča, Jaroslav.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Svobodová Vařeková, Radka.
    role:
      role term: author.
  name:
    name part: Pravda, Lukáš.
    role:
      role term: author.
  name:
    name part: Berka, Karel.
    role:
      role term: author.
  name:
    name part: Geidl, Stanislav.
    role:
      role term: author.
  name:
    name part: Sehnal, David.
    role:
      role term: author.
  name:
    name part: Otyepka, Michal.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2016
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIII, 144 p. 62 illus. online resource.
  abstract: A large amount of structural data on biomacromolecules is available and the number of resolved structures is growing rapidly. This implies that we have an increasing opportunity to perform so far unprecedented analyses to obtain crucial biological insight. Biomacromolecular structural fragments such as binding sites or active sites, ligands, channels, pores, secondary structure motifs, etc., become very promising objects for these analyses because such fragments often serve as drug targets or drug templates, or substrate-specific pathways. However, such analyses are very challenging due to their complexity and, consequently, also because they require application of a combination of different software tools. In this book, we describe individual steps necessary for analysis of biomacromolecular fragments and provide a lsit of software tools required to perform such steps. For each step, we also show corresponding web-based tools in detail and provide a few practical examples of their usage.
  table of contents: 1. Introduction -- 2. Biomacromolecular fragments -- 3. Databases -- 4. Detection & Extraction -- a. Biomacromolecular fragments and structural patterns -- b. channels and pores -- 5. Validation -- 6. Characterization -- a. Partial atomic charges -- b. Channel characteristics -- 7. Selected Examples.
  note: by Jaroslav Koča, Radka Svobodová Vařeková, Lukáš Pravda, Karel Berka, Stanislav Geidl, David Sehnal, Michal Otyepka.
  subject:
    topic: Medicine
  subject:
    topic: Biomedical engineering
  subject:
    topic: Bioinformatics
  subject:
    topic: Biomedicine
  subject:
    topic: Biomedical Engineering/Biotechnology
  subject:
    topic: Bioinformatics
  subject:
    topic: Computational Biology/Bioinformatics
  classification: R856-R857
  classification: 610.28
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: SpringerBriefs in Biochemistry and Molecular Biology
  identifier: 9783319473888
  identifier: http://dx.doi.org/10.1007/978-3-319-47388-8
  record info:
    record creation date: 170124
    record change date: 20170124120505.0
    record identifier: 978-3-319-47388-8