rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma
  name:
    name part: Martinez-Barbera, Juan Pedro.
    role:
      role term: editor.
  name:
    name part: Lilian Andoniadou, Cynthia.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2017
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XII, 220 p. 47 illus., 32 illus. in color. online resource.
  abstract: This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy. .
  table of contents: Pathogenesis of human ACP -- Transcriptomic and Genomic Analyses of Human Craniopharyngioma -- Genetically Modified Mouse Models of Adamantinomatous Craniopharyngioma -- Clinical Diagnosis of Human ACP -- Endocrine Deficits in Patients with Human Craniopharyngioma -- Obesity and metabolic disturbances in Adamantinomatous Craniopharyngioma Patients -- Radiology and Radiotherapy of Craniopharyngioma -- Surgical Treatment of Human ACP -- Intracystic Administration of Interferon-Alpha for Reduction of Cystic Tumour Burden -- Long-term Management and Clinical Trials in Adamantinomatous Craniopharyngioma.
  note: edited by Juan Pedro Martinez-Barbera, Cynthia Lilian Andoniadou.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Endocrinology
  subject:
    topic: Stem cells
  subject:
    topic: Medicine & Public Health
  subject:
    topic: Endocrinology
  subject:
    topic: Cancer Research
  subject:
    topic: Stem Cells
  classification: RC648-665.2
  classification: 616.4
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783319518909
  identifier: http://dx.doi.org/10.1007/978-3-319-51890-9
  record info:
    record creation date: 170420
    record change date: 20170420182813.0
    record identifier: 978-3-319-51890-9