rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Data Analytics for Protein Crystallization
  name:
    name part: Pusey, Marc L.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Aygün, Ramazan Savaş.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2017
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XX, 231 p. 66 illus., 56 illus. in color. online resource.
  abstract: This unique text/reference presents an overview of the computational aspects of protein crystallization, describing how to build robotic high-throughput and crystallization analysis systems. The coverage encompasses the complete data analysis cycle, including the set-up of screens by analyzing prior crystallization trials, the classification of crystallization trial images by effective feature extraction, the analysis of crystal growth in time series images, the segmentation of crystal regions in images, the application of focal stacking methods for crystallization images, and the visualization of trials. Topics and features: Describes the fundamentals of protein crystallization, and the scoring and categorization of crystallization image trials Introduces a selection of computational methods for protein crystallization screening, and the hardware and software architecture for a basic high-throughput system Presents an overview of the image features used in protein crystallization classification, and a spatio-temporal analysis of protein crystal growth Examines focal stacking techniques to avoid blurred crystallization images, and different thresholding methods for binarization or segmentation Discusses visualization methods and software for protein crystallization analysis, and reviews alternative methods to X-ray diffraction for obtaining structural information Provides an overview of the current challenges and potential future trends in protein crystallization This interdisciplinary work serves as an essential reference on the computational and data analytics components of protein crystallization for the structural biology community, in addition to computer scientists wishing to enter the field of protein crystallization. Dr. Marc L. Pusey is a Research Scientist at iXpressGenes, Inc. Huntsville, AL, USA. Dr. Ramazan Savaş Aygün is an Associate Professor in the Computer Science Department of the University of Alabama in Huntsville, USA.
  table of contents: Introduction to Protein Crystallization -- Scoring and Phases of Crystallization -- Computational Methods for Protein Crystallization Screening -- Robotic Image Acquisition -- Classification of Crystallization Trial Images -- Crystal Growth Analysis -- Focal Stacking for Crystallization Microscopy -- Crystal Image Region Segmentation -- Visualization -- Other Structure Determination Methods -- Future of Computational Protein Crystallization.
  note: by Marc L. Pusey, Ramazan Savaş Aygün.
  subject:
    topic: Computer science
  subject:
    topic: Molecular biology
  subject:
    topic: Biotechnology
  subject:
    topic: Data mining
  subject:
    topic: Image processing
  subject:
    topic: Bioinformatics
  subject:
    topic: Computer Science
  subject:
    topic: Computational Biology/Bioinformatics
  subject:
    topic: Data Mining and Knowledge Discovery
  subject:
    topic: Image Processing and Computer Vision
  subject:
    topic: Molecular Medicine
  subject:
    topic: Biotechnology
  classification: QH324.2-324.25
  classification: 570.285
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Computational Biology, 25
  identifier: 9783319589374
  identifier: http://dx.doi.org/10.1007/978-3-319-58937-4
  record info:
    record creation date: 171127
    record change date: 20171127142219.0
    record identifier: 978-3-319-58937-4