rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Sigma Proteins: Evolution of the Concept of Sigma Receptors
  name:
    name part: Kim, Felix J.
    role:
      role term: editor.
  name:
    name part: Pasternak, Gavril W.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2017
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 330 p. 64 illus., 32 illus. in color. online resource.
  abstract: Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly conserved among mammalian species, however, it does not share significant homology with any other mammalian protein. Although a range of structurally diverse small molecules bind Sigma1 with high affinity, and it has been associated with a broad range of signaling systems, Sigma1 itself has no known signaling or enzymatic activity. The evolution of this field over nearly four decades has more recently led to a fundamental shift in the concept of “sigma receptors” to what may more accurately and generally be called sigma proteins. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels. Sigma proteins have been linked to a range of physiological processes, including intracellular calcium signaling, neuroprotection, learning, memory, and cognition. Emerging genetic, clinical, and mechanism focused molecular pharmacology data demonstrate the involvement of proteins in a range of pathophysiologies and disorders including neurodegenerative disease, pain, addiction, psychomotor stimulant abuse, and cancer. However, an understanding of the physiological role of sigma proteins has remained elusive. Emerging data associate Sigma1 with chaperone-like activities or molecular scaffold functions. This book aims to provide an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology. It focusses on the reported roles of sigma proteins in pathophysiology and on emergent therapeutic initiatives.
  table of contents: Preface -- Historical perspective and background - including Sigma protein subtypes and ligand selectivity -- Sigma imaging agents -- Medicinal chemistry -- 3-dimensional homology models of Sigma1 -- Neuronal plasticity and ion channels -- Opioid receptors and other GPCR -- Cancer -- Neurodegenerative diseases -- Pain -- Cognition, learning, neurological disorders -- Drug abuse and addiction -- Alcohol Abuse -- Stroke and neuroprotection.
  note: edited by Felix J. Kim, Gavril W. Pasternak.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Human genetics
  subject:
    topic: Human physiology
  subject:
    topic: Neurosciences
  subject:
    topic: Pharmaceutical technology
  subject:
    topic: Biomedicine
  subject:
    topic: Neurosciences
  subject:
    topic: Human Physiology
  subject:
    topic: Human Genetics
  subject:
    topic: Cancer Research
  subject:
    topic: Pharmaceutical Sciences/Technology
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Handbook of Experimental Pharmacology, 244
  identifier: 9783319658537
  identifier: http://dx.doi.org/10.1007/978-3-319-65853-7
  record info:
    record creation date: 171005
    record change date: 20171005085311.0
    record identifier: 978-3-319-65853-7