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Right Ventricular Physiology, Adaptation and Failure in Congenital and Acquired Heart Disease
X, 267 p. 98 illus., 72 illus. in color. online resource.
This book spans topics in both congenital and acquired right heart disease providing readers with detailed information on the physiology, anatomy and myocardial mechanics of the right ventricle (RV), while describing the use of echo and MRI imaging to diagnose, and new developments in surgery and cardiac catheterization to treat. Right Ventricular Physiology, Adaptation and Failure in Congenital and Acquired Heart Disease includes extensive discussion of RV-pulmonary interactions, pulmonary hypertension and ventricular-ventricular interactions, including specific topics in embryology, fetal RV function, RV mechanics, pathophysiology of RV adaptation/ failure, molecular aspects of RV dysfunction, congenital heart disease, pulmonary arterial hypertension, pulmonary valve replacement, stem cell and future therapies. It is thus important reading for all cardiovascular medicine professionals, but especially pediatric cardiologists and surgeons, those who manage t hese patients in the cardiac care unit and investigators studying the RV. .
Introduction -- Embryological origins: How does the RV form? -- The fetal RV: systemic powerhouse or prone to fail? -- Metabolism and bioenergetics in the hypertrophied RV: what is different from the LV? -- Why does the RV myocardium fail? -- Does the RV really contract differently from the LV? -- How does the pressure loaded RV adapt and why does it fail? Macro and molecular perspectives -- Novel mechanisms of lung injury and repair in PAH: does success in the lab translate to hope for our patients? -- Right-left ventricular interactions in PAH -- From M-mode to 3D echo:-what should we use to assess RV function? -- What does MRI offer beyond volumes? -- Why is the RV different in TOF and in ASD? -- RV dyssynchrony and cardiac resynchronization therapy: New insights into mechanisms and pathophysiology -- The single right ventricle in the Fontan circulation: How does it work and why does it fail? -- Transcatheter pulmonary valve replacement: When should we pull the trigger? What do we hope to achieve? -- What should the echocardiographer tell me to plan tricuspid valve repair? -- Investigating the RV: What is the path going forward? -- Ventricular-vascular coupling in PAH: An engineer's perspective is relevant to the clinician -- The RV in cardiac transplantation-How do we know if it's going to cope and what do we do when it doesn't? -- Does the RV really contract differently from the LV? -- How can computer models contribute to the clinician's assessment of ventricular-ventricular interactions, ventricular-vascular interactions and RV failure? -- Can the RV support the failing LV -- Ebstein anomaly: Does echocardiographic assessment determine surgical repair? -- Arrhythmogenic right ventricular cardiomyopathy: Why does it happen and how do we make the diagnosis? -- Can surgeons preserve RV function in hypoplastic left heart syndrome? -- The RV in ccTGA: Why does it fail? Can we prevent it? -- Drugs? -- Assist devices -- News on the horizon.
edited by Mark K. Friedberg, Andrew N. Redington.