rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Heat Shock Proteins in the Immune System
  name:
    name part: Binder, Robert J.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: Srivastava, Pramod K.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2018
    edition: 1st ed. 2018.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: X, 185 p. 22 illus., 20 illus. in color. online resource.
  abstract: Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis. .
  table of contents: Introduction and history.- Part I: Structure of the HSPs in relation to chaperoning peptides and proteins -- Chapter 1: Hsp70-subsrate interactions -- Chapter 2: Molecular Chaperone Inhibitors.- Part II: Exposure of HSPs to immune cells -- Chapter 3: Extracellular Heat Shock Proteins as Stress Communication Signals.- Part III: Regulation of immune responses by extracellular HSPs -- Chapter 4: The Heat Shock Protein-CD91 pathway and Tumor Immuno-surveillance -- Chapter 5: Bridging the gaps in the vaccine development: Avant-garde vaccine approach with secreted heat shock protein gp96-Ig -- Chapter 6: Regulation of the Extracellular Matrix by Heat Shock Proteins and Molecular Chaperones -- Chapter 7: Heat shock protein mediated T cell responses in pathogen infections -- Chapter 8: An ancestral immune surveillance system in the amphibian Xenopus connecting certain heat shock proteins with classical and nonclassical MHC class I molecules -- Chapter 9: Inhibition of HSPs for Enhanced Immunity. .
  note: edited by Robert J. Binder, Pramod K. Srivastava.
  subject:
    topic: Immunology
  subject:
    topic: Proteins
  subject:
    topic: Infectious diseases
  subject:
    topic: Cancer research
  subject:
    topic: Immunology
  subject:
    topic: Protein Science
  subject:
    topic: Infectious Diseases
  subject:
    topic: Cancer Research
  classification: QR180-189.5
  classification: 616.079
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783319690421
  identifier: https://doi.org/10.1007/978-3-319-69042-1
  record info:
    record creation date: 180409
    record change date: 20191026091412.0
    record identifier: 978-3-319-69042-1