rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Nuclear Pore Complexes in Genome Organization, Function and Maintenance
  name:
    name part: D'Angelo, Maximiliano.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2018
    edition: 1st ed. 2018.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 240 p. 32 illus. in color. online resource.
  abstract: The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome. .
  note: edited by Maximiliano D'Angelo.
  subject:
    topic: Medical genetics
  subject:
    topic: Gene expression
  subject:
    topic: Cell biology
  subject:
    topic: Gene Function
  subject:
    topic: Gene Expression
  subject:
    topic: Cell Biology
  classification: RB155-155.8
  classification: QH431
  classification: 611.01816
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783319716145
  identifier: https://doi.org/10.1007/978-3-319-71614-5
  record info:
    record creation date: 180202
    record change date: 20191027002656.0
    record identifier: 978-3-319-71614-5