rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Drug Resistance in Leishmania Parasites
    sub title: Consequences, Molecular Mechanisms and Possible Treatments
  name:
    name part: Ponte-Sucre, Alicia.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: Padrón-Nieves, Maritza.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2018
    edition: 2nd ed. 2018.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVII, 376 p. 24 illus., 14 illus. in color. online resource.
  abstract: Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the second edition of a well-received book that provides a comprehensive update on the pathology of the disease, as well as on the concept of parasitic drug resistance, its molecular basis, consequences and possible treatments. A valuable resource for scientists both from academia and industry involved in biomedical research and drug design, the book provides the knowledge needed to understand leishmaniasis and to contibute to combatting this disease worldwide.
  table of contents: Prologue -- Introduction -- Part I Determinant features in Leishmaniasis -- Molecular evolution and phylogeny of Leishmania -- The role of reservoirs: canine Leishmaniasis -- Epidemiology of Leishmaniasis in the time of drug resistance -- The role of the immune system in resistance to infection -- Part II Challenges in the diagnosis, treatment and control of Leishmaniasis in the times of drug resistance -- Co-infection with HIV -- Visceral Leishmaniasis -- Tegumentary Leishmaniasis -- Antimony accounted sequel post Kala-Azar dermal Leishmaniasis -- Part III Molecular featrues of drug resistant Leishmania -- Genetic Expression and drug resistance, the role of proteomics -- The role of AMC transporters in drug-resistant Leishmania -- Functional analysis of Leishmania membrane (non AMC) transporters involved in drug resistance -- Part IV Pharmacology and chemotherapy of Leishmaniasis -- Classical vs. novel treatment regimens -- Bioinformatics in Leishmania drug design -- Leishmanis mitochondria, a druggable organelle -- P-glycoprotein-like transporters in Leishmania: a search for reversal agents -- Part V Strategies to circumvent drug resistance in Leishmania -- The relevance of susceptibility tests, breakpoints and markers -- The concept of fitness in Leishmania.
  note: edited by Alicia Ponte-Sucre, Maritza Padrón-Nieves.
  subject:
    topic: Drug resistance
  subject:
    topic: Infectious diseases
  subject:
    topic: Pharmaceutical technology
  subject:
    topic: Vaccines
  subject:
    topic: Parasitology
  subject:
    topic: Microbiology
  subject:
    topic: Drug Resistance
  subject:
    topic: Infectious Diseases
  subject:
    topic: Pharmaceutical Sciences/Technology
  subject:
    topic: Vaccine
  subject:
    topic: Parasitology
  subject:
    topic: Microbiology
  classification: QR177
  classification: 616.9041
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783319741864
  identifier: https://doi.org/10.1007/978-3-319-74186-4
  record info:
    record creation date: 180823
    record change date: 20191027232228.0
    record identifier: 978-3-319-74186-4