rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Nuclear-Cytoplasmic Transport
  name:
    name part: Yang, Weidong.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2018
    edition: 1st ed. 2018.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VI, 274 p. 44 illus., 40 illus. in color. online resource.
  abstract: Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
  table of contents: Assembly of the nuclear pore complex -- Structure of Yeast nuclear pore complexes -- Structure and function of nucleoporins in nuclear transport -- Dynamic structures of the nuclear pore complex and their roles in nucleo-cytoplasmic transport -- Non-canonical roles of nuclear pore proteins -- On the role of the channel nucleoporins in nuclear transport -- Structures of Importins and Exportins -- Navigating the Nuclear Envelope: one or multiple transport mechanisms for integral membrane proteins? -- mRNA export and its dysregulation in disease -- Coarse-grained molecular dynamics of the natively-unfolded domain of the NPC -- On the effects of leukemogenic nucleoporin fusion proteins on nucleocytoplasmic transport and gene expression -- Structure and Function of the Nuclear Pore Complex Revealed by Advanced Fluorescence Microscopy.
  note: edited by Weidong Yang.
  subject:
    topic: Nucleic acids
  subject:
    topic: Microbiology
  subject:
    topic: Evolutionary biology
  subject:
    topic: Nucleic Acid Chemistry
  subject:
    topic: Applied Microbiology
  subject:
    topic: Eukaryotic Microbiology
  subject:
    topic: Evolutionary Biology
  classification: QD433-436
  classification: 572.84
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Nucleic Acids and Molecular Biology, 33
  identifier: 9783319773094
  identifier: https://doi.org/10.1007/978-3-319-77309-4
  record info:
    record creation date: 180727
    record change date: 20191023213319.0
    record identifier: 978-3-319-77309-4