rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Gene Therapy in Reconstructive and Regenerative Surgery
  name:
    name part: Giatsidis, Giorgio.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2018
    edition: 1st ed. 2018.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VII, 113 p. 8 illus., 7 illus. in color. online resource.
  abstract: This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided. Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants. Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.
  table of contents: Principles of Gene Therapy in Reconstructive and Regenerative Surgery -- Gene Therapy in Skin and Wound Healing -- Gene Therapy in Pathologic Scars -- Gene Therapy in Skeletal Muscle Repair and Regeneration -- Gene Therapy in Cartilage Repair and Regeneration -- Gene Therapy in Tendon Repair and Regeneration -- Gene Therapy and Free Flaps for Therapeutic Reconstructive Surgery -- Developing a Gene Therapy Clinical Trial: Tips and Tricks -- Future Directions in Reconstructive and Regenerative Surgery.
  note: edited by Giorgio Giatsidis.
  subject:
    topic: Plastic surgery
  subject:
    topic: Regenerative medicine
  subject:
    topic: Tissue engineering
  subject:
    topic: Plastic Surgery
  subject:
    topic: Regenerative Medicine/Tissue Engineering
  classification: RD118-120.5
  classification: 617.952
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783319789576
  identifier: https://doi.org/10.1007/978-3-319-78957-6
  record info:
    record creation date: 180802
    record change date: 20191025211228.0
    record identifier: 978-3-319-78957-6