rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Stress, Trauma and Synaptic Plasticity
  name:
    name part: Bennett, Maxwell.
    role:
      role term: creator
    role:
      role term: author.
    role:
      role term: aut
    role:
      role term: http://id.loc.gov/vocabulary/relators/aut
  name:
    name part: Lagopoulos, Jim.
    role:
      role term: author.
    role:
      role term: aut
    role:
      role term: http://id.loc.gov/vocabulary/relators/aut
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2018
    edition: 1st ed. 2018.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXXIII, 231 p. 47 illus., 18 illus. in color. online resource.
  abstract: This book provides detailed insights into the cellular and molecular alterations that occur in the brain following stress and trauma. The changes to the grey matter in certain areas of the brain are similar in stressed humans and animals, with the most likely basis for these changes being the degeneration of synaptic connections. In the book's initial sections, the reader will learn about the core network of synaptic connections that are affected by stress and trauma disorders. These connections are chiefly modulated by dopamine, serotonin and Brain Derived Neurotrophic Factor (BDNF). In subsequent chapters, the NMDA-receptor-mediated plasticity of these synapses is discussed, with particular attention paid to how glucocorticoids can interfere with the function of BDNF and thereby affect the synapse's physical stability. The book concludes by integrating the observations made in the previous sections so as to present plausible hypotheses regarding the identity of the networks, synapses and molecular pathways that promote fear and extinction. Providing an up-to-date overview of the mechanisms of synaptic plasticity and physiological changes in the stressed and traumatized brain, this book will appeal to researchers, clinicians and students in the neurosciences.
  table of contents: Grey matter changes in the brain following stress and trauma -- Synaptic changes responsible for grey matter changes in the brain of animal models following stress -- Identification of the core neural network subserving PTSD in animal models and their modulation -- Modulation of the core neural network in stress: the role of Brain Derived Neurotrophic Factor & LTP -- Modulation of the core neural network in stress: the role of Endocannabinoids & LTD -- Functioning of the core neural network in fear and extinction -- Modulation of the core synaptic network in extinction: the role of Brain Derived Neurotrophic Factor -- Appendix 1: F-actin determination of dendritic spine integrity -- Appendix 2: Regulation of NMDA receptors. .
  note: by Maxwell Bennett, Jim Lagopoulos.
  subject:
    topic: Neurosciences
  subject:
    topic: Neurobiology
  subject:
    topic: Neurology
  subject:
    topic: Neurosciences
  subject:
    topic: Neurobiology
  subject:
    topic: Neurology
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783319911168
  identifier: https://doi.org/10.1007/978-3-319-91116-8
  record info:
    record creation date: 190201
    record change date: 20191025131349.0
    record identifier: 978-3-319-91116-8