rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Stem Cells
  name:
    name part: Wobus, Anna M.
    role:
      role term: editor.
  name:
    name part: Boheler, Kenneth R.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2006
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XII, 414 p. 53 illus., 18 illus. in color. online resource.
  abstract: Signi?cant advances in stem cell research and their potentials for therap- tic applications have attracted the attention of the scienti?c community and captured the imagination of society as a whole. Not so long ago, the study of most stem cells, other than those that regenerated the haematopoietic system, was rather obscure and limited to a relatively small number of researchers and laboratories. The uproar over stem cells really began in 1998 with the s- cessful derivation of pluripotent human embryonic stem (ES) cells by James Thomson and co-workers. This breakthrough and the subsequent generation of specialized human cells in vitro led to a paradigm shift within the sci- ti?c community, which transformed this specialized endeavour from a topic of scienti?c interest to a line of investigation with the potential to generate cells - pable of treating serious ailments, including diabetes, cardiovascular diseases and neurodegenerative disorders. Thus the dawn of regenerative medicine has spawned from the somewhat esoteric study of stem cells. Since 1998, extensive research endeavours have been devoted to the study of both embryonic and adult stem cells. Early reports suggested that adult stem cells had a higher plasticity than previously believed, perhaps even comparable with that demonstrated by embryonic stem cells, but several observations of the so-called transdifferentiation capacity and plasticity of adult stem cells have not been repeated. These reports, however, encouraged on-going debates about the capacity of adult versus embryonic stem cells and their potential use in regenerative medicine.
  table of contents: Factors Involved in Self-Renewal and Pluripotency of Embryonic Stem Cells -- Embryonic Stem Cell-Derived Embryoid Bodies: An In Vitro Model of Eutherian Pregastrulation Development and Early Gastrulation -- Embryonic Stem Cells: A Novel Tool for the Study of Antiangiogenesis and Tumor-Induced Angiogenesis -- Cardiac Repair by Embryonic Stem-Derived Cells -- Cardiomyocytes from Human Embryonic Stem Cells -- Autocrine and Intracrine Signaling for Cardiogenesis in Embryonic Stem Cells: A Clue for the Development of Novel Differentiating Agents -- Therapeutic Potential of Stem Cells in Diabetes -- The Stem Cell Continuum: A New Model of Stem Cell Regulation -- Markers of Adult Tissue-Based Stem Cells -- Designer Cytokines for Human Haematopoietic Progenitor Cell Expansion: Impact for Tissue Regeneration -- Mesenchymal Stem Cells: Isolation, In Vitro Expansion and Characterization -- Neovascularization and Cardiac Repair by Bone Marrow-Derived Stem Cells -- The Potential Use of Myogenic Stem Cells in Regenerative Medicine -- Neural Stem Cells: On Where They Hide, in Which Disguise, and How We May Lure Them Out -- Cell Transplantation for Patients with Parkinson’s Disease -- Postmodern Biology: (Adult) (Stem) Cells Are Plastic, Stochastic, Complex, and Uncertain.
  note: edited by Anna M. Wobus, Kenneth R. Boheler.
  subject:
    topic: Medicine
  subject:
    topic: Human genetics
  subject:
    topic: Neurosciences
  subject:
    topic: Pharmacology
  subject:
    topic: Biomedicine
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Human Genetics
  subject:
    topic: Neurosciences
  classification: RM1-950
  classification: 615
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Handbook of Experimental Pharmacology, 174
  identifier: 9783540312659
  identifier: http://dx.doi.org/10.1007/3-540-31265-X
  record info:
    record creation date: 100301
    record change date: 20151204145946.0
    record identifier: 978-3-540-31265-9