rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Chemokines and Viral Infection
  name:
    name part: Lane, Thomas E.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2006
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XI, 160 p. online resource.
  abstract: This edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens.
  table of contents: Functional Diversity of Chemokines and Chemokine Receptors in Response to Viral Infection of the Central Nervous System -- Cytokine and Chemokine Networks: Pathways to Antiviral Defense -- Herpes Simplex Virus and the Chemokines That Mediate the Inflammation -- Influence of Proinflammatory Cytokines and Chemokines on the Neuropathogenesis of Oncornavirus and Immunosuppressive Lentivirus Infections -- HIV-1 Coreceptors and Their Inhibitors -- A Viral Conspiracy: Hijacking the Chemokine System Through Virally Encoded Pirated Chemokine Receptors.
  note: edited by Thomas E. Lane.
  subject:
    topic: Medicine
  subject:
    topic: Medical microbiology
  subject:
    topic: Biomedicine
  subject:
    topic: Medical Microbiology
  classification: QR46
  classification: 616.9041
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Current Topics in Microbiology and Immunology, 303
  identifier: 9783540333975
  identifier: http://dx.doi.org/10.1007/978-3-540-33397-5
  record info:
    record creation date: 100301
    record change date: 20151204164823.0
    record identifier: 978-3-540-33397-5