rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Analgesia
  title info:
    title: With contributions by numerous experts
  name:
    name part: Stein, Christoph.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2007
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 435 p. online resource.
  abstract: Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular methods and of the now common use of animal models of pathological, rather than physiological, pain. These important issues are elaborated in the introductory chapter. In parallel, c- temporaryinterdisciplinarytreatmentapproacheshavetaughtusthatsomatic mechanisms alone cannot explain pain; it is an experience shaped as well by social context, memory, and other psychological phenomena. Thus, the book closes with two chapters putting pharmacological strategies into a broader perspective. All of these advancements culminate in the contemporary c- mon goal of developing mechanism-based rather than empiric approaches to thetreatment ofpain.
  table of contents: Peripheral and Central Mechanisms of Pain Generation -- Drugs in Clinical Use -- Opioids -- Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamol and Pyrazolinones -- Local Anesthetics -- Serotonin Receptor Ligands: Treatments of Acute Migraine and Cluster Headache -- Anti-convulsants and Anti-depressants -- Compounds in Preclinical Development -- Neuropeptide and Kinin Antagonists -- Glutamate Receptor Ligands -- Adrenergic and Cholinergic Compounds -- Cannabinoids and Pain -- Future Targets in Analgesia Research -- Adenosine and ATP Receptors -- Ion Channels in Analgesia Research -- Protein Kinases as Potential Targets for the Treatment of Pathological Pain -- Pain Management Beyond Pharmacotherapy -- Placebo and Endogenous Mechanisms of Analgesia -- Limitations of Pharmacotherapy: Behavioral Approaches to Chronic Pain.
  note: edited by Christoph Stein.
  subject:
    topic: Medicine
  subject:
    topic: Pharmacology
  subject:
    topic: Anesthesiology
  subject:
    topic: Rheumatology
  subject:
    topic: Neurosurgery
  subject:
    topic: Surgery
  subject:
    topic: Psychology
  subject:
    topic: Biomedicine
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Anesthesiology
  subject:
    topic: Psychology, general
  subject:
    topic: Rheumatology
  subject:
    topic: Surgery
  subject:
    topic: Neurosurgery
  classification: RM1-950
  classification: 615
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Handbook of Experimental Pharmacology, 177
  identifier: 9783540338239
  identifier: http://dx.doi.org/10.1007/978-3-540-33823-9
  record info:
    record creation date: 100301
    record change date: 20151204144540.0
    record identifier: 978-3-540-33823-9