rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Insights into Receptor Function and New Drug Development Targets
  name:
    name part: Conn, Michael.
    role:
      role term: editor.
  name:
    name part: Kordon, Claude.
    role:
      role term: editor.
  name:
    name part: Christen, Yves.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2006
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 202 p. online resource.
  abstract: G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPCR-directed drugs account for approximately $40 billion in sales and, of drugs at market, approximately 70% target GPCR function. The availability of combinatorial chemistry coupled with high throughput screening techniques have facilitated discovery of peptidic and non-peptidic ligands of membrane receptors. Mutant receptor models have revealed their role in health and disease and provided insight to new therapeutic approaches, based on control of protein trafficking. Understanding receptor-receptor interactions has provided one mechanism for receptor cross-talk and revealed unexpected interactions. The completion of the human genome has identified a new source of therapeutic targets: "orphan receptors" with unknown functions and yet-to-be discovered ligands. Some orphans have now been identified as ghrelin, nociceptin, apelin, and urocortin. This finding, along with important technologies to develop ligands with desirable characteristics, including peptidomimetics is likely to further accelerate interest in this area.
  table of contents: Molecular and functional diversity of the TRPC family of ion channels. TRPC channels and their role in ROCE/SOCE -- Functional Rescue of Misfolded Receptor Mutants -- Obesity-related mutations of leptin and melanocortin receptors -- cAMP- and cGMP-dependent control of lipolysis and lipid mobilization in humans: putative targets for fat cell management -- Central Neuropeptide Receptors Involved in Water Balance: Application to Apelin -- Targeting regulators of G protein signaling (RGS proteins) to enhance agonist specificity -- Dimeric GPCRs: what did we learn from the metabotropic glutamate receptors? -- Guiding principles applied in the design of GPCR-selective hypothalamic hormone agonists and antagonists -- Mutations in G proteins and G protein-coupled receptors in human endocrine diseases -- A molecular dissection of the glycoprotein hormone receptors -- Receptor Tyrosine Kinases as Targets for Cancer Therapy Development -- Targets for pituitary tumor therapy -- The endogenous cannabinoid system in the control of food intake and energy balance.
  note: edited by Michael Conn, Claude Kordon, Yves Christen.
  subject:
    topic: Medicine
  subject:
    topic: Pharmacology
  subject:
    topic: Endocrinology
  subject:
    topic: Biomedicine
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Biomedicine general
  subject:
    topic: Endocrinology
  classification: RM1-950
  classification: 615
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Research and Perspectives in Endocrine Interactions
  identifier: 9783540344476
  identifier: http://dx.doi.org/10.1007/3-540-34447-0
  record info:
    record creation date: 100301
    record change date: 20151204180915.0
    record identifier: 978-3-540-34447-6