rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Tissue-Specific Estrogen Action
    sub title: Novel Mechanisms, Novel Ligands, Novel Therapies
  name:
    name part: Korach, K. S.
    role:
      role term: editor.
  name:
    name part: Wintermantel, T.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2007
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 181 p. online resource.
  abstract: Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled “The Second Decade” and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the signaling pathways mediated by these receptors warrant further research, even though in principle they appeared to represent the most immediate, seemingly simple signaling pathway from hormone (ligand) binding to gene expression changes. In nuclear receptor molecular biology, estrogen receptor research has additional unique facets: since the discovery of ethinyl estradiol by Inhoffen and Hohlweg in the laboratories of Schering AG in the 1930s—and therefore several decades longer than nuclear receptor - searchitself—estrogenreceptorshavebeentargetsofwidelyused,orally administered drugs. Thus, accumulating clinical experience on estrogen action in vivo helps to support the progress in molecular biological research.
  table of contents: Interfering with the Dynamics of Estrogen Receptor-Regulated Transcription -- Actions of Estrogen and Estrogen Receptors in Nonclassical Target Tissues -- Genetic Dissection of Estrogen Receptor Signaling In Vivo -- Of Mice and Men: The Many Guises of Estrogens -- Estradiol Action in Atherosclerosis and Reendothelialization -- Functional Effects and Molecular Mechanisms of Subtype-Selective ER? and ER? Agonists in the Cardiovascular System -- Pathogenesis and Therapy of Rheumatoid Arthritis -- The Role of ER? and ER? in theProstate: Insights from Genetic Models and Isoform-Selective Ligands -- Preclinical Characterization of Selective Estrogen Receptor ? Agonists: New Insights into Their Therapeutic Potential -- Exploiting Nongenomic Estrogen Receptor-Mediated Signaling for the Development of Pathway-Selective Estrogen Receptor Ligands.
  note: edited by K. S. Korach, T. Wintermantel.
  subject:
    topic: Medicine
  subject:
    topic: Human physiology
  subject:
    topic: Molecular biology
  subject:
    topic: Pharmacology
  subject:
    topic: Gynecology
  subject:
    topic: Endocrinology
  subject:
    topic: Medical biochemistry
  subject:
    topic: Biomedicine
  subject:
    topic: Human Physiology
  subject:
    topic: Endocrinology
  subject:
    topic: Gynecology
  subject:
    topic: Medical Biochemistry
  subject:
    topic: Molecular Medicine
  subject:
    topic: Pharmacology/Toxicology
  classification: QP34-38
  classification: 612
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Ernst Schering Foundation Symposium Proceedings, 2006/1
  identifier: 9783540495482
  identifier: http://dx.doi.org/10.1007/978-3-540-49548-2
  record info:
    record creation date: 100301
    record change date: 20151204190158.0
    record identifier: 978-3-540-49548-2