rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Tubulin-Binding Agents
    sub title: Synthetic, Structural and Mechanistic Insights
  name:
    name part: Carlomagno, Teresa.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2009
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XI, 331 p. online resource.
  abstract: reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a “time-resolved” picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology.
  table of contents: Macrolide-Based Microtubule-Stabilizing Agents – Chemistry and Structure–Activity Relationships -- The Chemical Synthesis of Discodermolide -- The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels -- The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR -- The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography -- Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin -- Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents.
  note: edited by Teresa Carlomagno.
  subject:
    topic: Chemistry
  subject:
    topic: Cancer research
  subject:
    topic: Analytical chemistry
  subject:
    topic: Organic chemistry
  subject:
    topic: Medicinal chemistry
  subject:
    topic: Biochemistry
  subject:
    topic: Chemistry
  subject:
    topic: Medicinal Chemistry
  subject:
    topic: Biochemistry, general
  subject:
    topic: Cancer Research
  subject:
    topic: Organic Chemistry
  subject:
    topic: Analytical Chemistry
  classification: RS400-431
  classification: 615.19
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Topics in Current Chemistry, 286
  identifier: 9783540690399
  identifier: http://dx.doi.org/10.1007/978-3-540-69039-9
  record info:
    record creation date: 100301
    record change date: 20151116132725.0
    record identifier: 978-3-540-69039-9