rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Biopacemaking
  name:
    name part: Spaan, J. A. E.
    role:
      role term: editor.
  name:
    name part: Coronel, Ruben.
    role:
      role term: editor.
  name:
    name part: Bakker, Jacques M. T. de.
    role:
      role term: editor.
  name:
    name part: Zaza, Antonio.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2007
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 182 p. online resource.
  abstract: The development of a bio-engineered pacemaker is of substantial clinical and also scientific interest because it promises to overcome several limitations of electronic pacemakers. Moreover it may answer the longstanding question of whether the complex structure of the sinus node is indeed a prerequisite for reliable pacemaking, or simpler structures might work as well. This book gives an overview of the current state-of-the-art of creating a bio-engineered pacemaker. It shows the approaches to develop of genetic and cell-based engineering methods suitable to implement them with safety and stability. It also illuminates the problems that need to be solved before bio-pacemaking can be considered for clinical use.
  table of contents: Biopacemaking: Clinically Attractive, Scientifically a Challenge -- Embryological Development of Pacemaker Hierarchy and Membrane Currents Related to the Function of the Adult Sinus Node: Implications for Autonomic Modulation of Biopacemakers -- Creation of a Biological Pacemaker by Gene- or Cell-Based Approaches -- Creating a Cardiac Pacemaker by Gene Therapy -- Biological Pacemakers Based on If -- Gene Therapy to Create Biological Pacemakers -- Inhibition of Cardiomyocyte Automaticity by Electrotonic Application of Inward Rectifier Current from Kir2.1 Expressing Cells -- Propagation of Pacemaker Activity -- Computer Modelling of the Sinoatrial Node -- Application of Mesenchymal Stem Cell-Derived Cardiomyocytes as Bio-pacemakers: Current Status and Problems to Be Solved -- Enrichment of Cardiac Pacemaker-Like Cells: Neure gulin-1 and Cyclic amp Increase If-Current Density and Connexin 40 mRNA Levels in Fetal Cardiomyocytes.
  note: edited by J. A. E Spaan, Ruben Coronel, Jacques M. T. de Bakker, Antonio Zaza.
  subject:
    topic: Engineering
  subject:
    topic: Human physiology
  subject:
    topic: Cardiology
  subject:
    topic: Application software
  subject:
    topic: Biophysics
  subject:
    topic: Biological physics
  subject:
    topic: Biomedical engineering
  subject:
    topic: Engineering
  subject:
    topic: Biomedical Engineering
  subject:
    topic: Human Physiology
  subject:
    topic: Computer Applications
  subject:
    topic: Biophysics and Biological Physics
  subject:
    topic: Cardiology
  classification: R856-857
  classification: 610.28
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Series in Biomedical Engineering
  identifier: 9783540721109
  identifier: http://dx.doi.org/10.1007/978-3-540-72110-9
  record info:
    record creation date: 100301
    record change date: 20151204190200.0
    record identifier: 978-3-540-72110-9