rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Alzheimer's Disease
  title info:
    title: With contributions by numerous experts
  name:
    name part: Lau, Lit-Fui.
    role:
      role term: editor.
  name:
    name part: Brodney, Michael A.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2008
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIII, 179 p. online resource.
  abstract: Alzheimer’s disease (AD) is a neurodegenerative disease that robs the minds of our elderly population. Approximately one in every eight adults over the age of 65 and nearly half of those over 85 are afflicted with this disease. The aging population in developed societies will impose an ever increasing socioeconomic threat in the future. Current medicines for AD patients are mainly symptomatic treatments and a huge unmet medical need exists to slow the progression of this disease. A great deal of research has been dedicated to understanding the pathogenesis of AD from which comes many ideas for intervening with its progression. Some of these ideas have been fast-tracked to clinical trials due to the availability of medicines with proven clinical efficacies for other diseases (e.g. atorvastatin, simvastatin, rosiglitazone and clioquinol) while others represent novel chemical entities (e.g. glycogen synthase kinase-3 inhibitors). This volume will first review existing cholinesterase inhibitors prescribed for AD patients followed by some target mechanisms with ongoing clinical trials. It offers a glimpse of what our future medicine cabinets may look like for AD patients. It also provides an interesting read on why and how current medicines for other indications could potentially be used to treat AD.
  table of contents: Therapeutic Approaches for the Treatment of Alzheimer's Disease: An Overview -- Cholinesterase Inhibitors -- Beyond Cholesterol: Statin Benefits in Alzheimer's Disease -- PPAR? Agonists for the Treatment of Alzheimer's Disease -- Metal Complexing Agents for the Treatment of Alzheimer's Disease -- GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.
  note: edited by Lit-Fui Lau, Michael A. Brodney.
  subject:
    topic: Chemistry
  subject:
    topic: Molecular biology
  subject:
    topic: Pharmacology
  subject:
    topic: Organic chemistry
  subject:
    topic: Medicinal chemistry
  subject:
    topic: Chemistry
  subject:
    topic: Medicinal Chemistry
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Organic Chemistry
  subject:
    topic: Molecular Medicine
  classification: RS400-431
  classification: 615.19
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Topics in Medicinal Chemistry, 2
  identifier: 9783540742296
  identifier: http://dx.doi.org/10.1007/978-3-540-74229-6
  record info:
    record creation date: 100301
    record change date: 20151125151048.0
    record identifier: 978-3-540-74229-6