rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Pharmacology of Neurotransmitter Release
  name:
    name part: Südhof, Thomas C.
    role:
      role term: editor.
  name:
    name part: Starke, Klaus.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2008
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIV, 582 p. online resource.
  abstract: It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the book’s second part, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process. These include ligand-gated ion channels and presynaptic G-protein-coupled receptors. The targets of presynaptic receptors within the exocytosis cascade, and their therapeutic potential, are subjects addressed in the majority of chapters.
  table of contents: Neurotransmitter Release -- Pharmacology of Neurotransmitter Release: Measuring Exocytosis -- Presynaptic Calcium Channels: Structure, Regulators, and Blockers -- Pharmacology of Neurotransmitter Transport into Secretory Vesicles -- Core Proteins of the Secretory Machinery -- Presynaptic Neurotoxins with Enzymatic Activities -- ?-Latrotoxin and Its Receptors -- Presynaptic Signaling by Heterotrimeric G-Proteins -- Presynaptic Metabotropic Receptors for Acetylcholine and Adrenaline/Noradrenaline -- Presynaptic Receptors for Dopamine, Histamine, and Serotonin -- Presynaptic Adenosine and P2Y Receptors -- Presynaptic Metabotropic Glutamate and GABA B Receptors -- Presynaptic Neuropeptide Receptors -- Presynaptic Modulation by Endocannabinoids -- Presynaptic lonotropic Receptors -- NO/cGMP-Dependent Modulation of Synaptic Transmission -- Therapeutic Use of Release-Modifying Drugs.
  note: edited by Thomas C. Südhof, Klaus Starke.
  subject:
    topic: Medicine
  subject:
    topic: Human physiology
  subject:
    topic: Neurosciences
  subject:
    topic: Pharmacology
  subject:
    topic: Neurology
  subject:
    topic: Biomedicine
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Neurosciences
  subject:
    topic: Neurology
  subject:
    topic: Human Physiology
  classification: RM1-950
  classification: 615
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Handbook of Experimental Pharmacology, 184
  identifier: 9783540748052
  identifier: http://dx.doi.org/10.1007/978-3-540-74805-2
  record info:
    record creation date: 100301
    record change date: 20151204163310.0
    record identifier: 978-3-540-74805-2