rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: Subthalamic Nucleus Part II: Modelling and Simulation of Activity
  name:
    name part: Heida, Tjitske.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Marani, Enrico.
    role:
      role term: author.
  name:
    name part: Usunoff, Kamen G.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2008
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: online resource.
  abstract: This monograph gives an overview of the STN. It treats the position of the STN in hemiballism, based on older and recent data. The cytology encompasses the neuronal types present in the STN in nearly all studied species and focuses on interneurons and the extent of their dendrites. Ultrastructural features are described for cat and baboon (F1, F2, Sr, LR1, LR2 boutons and d.c.v. terminals, together with vesicle containing dendrites), the cytochemistry is focused on receptors (dopamine, cannabinoid, opioid, glutamate, GABA, serotonin, and cholinergic-, purinergic ones) and calcium binding proteins and calcium channels. The development of the subthalamic nucleus from the subthalamic cell cord is given together with its developing connections. The topography of rat, cat, baboon and man is worked out as to cytology, sagittal borders, surrounding nuclei and tracts, and aging of the human STN. The connections of the STN are extensively elaborated on: cortical-, subthalamo-cortical-, pallidosubthalamic-, pedunculopontine-, raphe-, thalamic-, central grey-, and nigral connections. Emphasis is put on human connections. Recent nigro-subthalamic studies showed a contralateral projection. The role of the STN in the basal ganglia circuitry is described as to the direct, indirect and hyperdirect pathway. The change the STN undergoes in Parkinson’s disease in neuronal firing rate and firing pattern is demonstrated together with the possible mechanisms of deep brain stimulation. The results of in vitro measurements on dissociated cultured subthalamic neurons are presented. The preliminary effects of application of acetylcholine and high frequency stimulation are described. This part is preceded with studies concerning spontaneous activity, depolarizing and hyperpolarizing inputs, synaptic inputs, high frequency stimulation, and burst activity of STN cells. The last extensive part concerns STN cell models and simulation of neuronal networks. Single cell models (model of Otsuka and T…
  table of contents: The Basal Ganglia -- STN Activity Recorded in Vitro: Brain Slices -- STN Activity Recorded in Vitro: Dissociated Cell Cultures -- STN Cell Models and Simulation of Neuronal Networks -- Comparison of Part I and Part II.
  note: by Tjitske Heida, Enrico Marani, Kamen G. Usunoff.
  subject:
    topic: Medicine
  subject:
    topic: Neurosciences
  subject:
    topic: Biomedicine
  subject:
    topic: Neurosciences
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Advances in Anatomy, Embryology and Cell Biology, 199
  identifier: 9783540794622
  identifier: http://dx.doi.org/10.1007/978-3-540-79462-2
  record info:
    record creation date: 100301
    record change date: 20131219160503.0
    record identifier: 978-3-540-79462-2