rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Small Molecules in Oncology
  name:
    name part: Martens, Uwe M.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2010
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 238 p. online resource.
  abstract: Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.
  table of contents: Protein kinase inhibitors -- Imatinib Mesylate -- Erlotinib -- Axitinib (AG-013736) -- Lapatinib -- Sorafenib -- Sunitinib -- Dasatinib -- Nilotinib -- Bosutinib -- Epigenetic modifiers -- Decitabine -- 5-Azacytidine/Azacitidine -- Cell cycle inhibitors -- Bortezomib -- Temsirolimus -- Danusertib (formerly PHA-739358) – A Novel Combined Pan-Aurora Kinases and Third Generation Bcr-Abl Tyrosine Kinase Inhibitor -- BI_2536 - Targeting the Mitotic Kinase Polo-Like Kinase 1 (Plk1) -- Other novel agents -- Imetelstat (GRN163L) - Telomerase-Based Cancer Therapy -- GDC-0449 - Targeting the Hedgehog Signaling Pathway.
  note: edited by Uwe M. Martens.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Hematology
  subject:
    topic: Oncology
  subject:
    topic: Medicine & Public Health
  subject:
    topic: Oncology
  subject:
    topic: Hematology
  subject:
    topic: Cancer Research
  classification: RC254-282
  classification: 616.994
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Recent Results in Cancer Research, 184
  identifier: 9783642012228
  identifier: http://dx.doi.org/10.1007/978-3-642-01222-8
  record info:
    record creation date: 100301
    record change date: 20151204182203.0
    record identifier: 978-3-642-01222-8