rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Laron Syndrome - From Man to Mouse
    sub title: Lessons from Clinical and Experimental Experience
  name:
    name part: Laron, Zvi.
    role:
      role term: editor.
  name:
    name part: Kopchick, J.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIV, 531 p. 447 illus. in color. online resource.
  abstract: Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.
  table of contents: From the Content: Part I - Laron Syndrome in Man -- Clinical Aspects -- History of the Israeli Cohort of Laron Syndrome Patients -- Early Investigations -- Clinical Evidence of Growth Hormone Resistance in Patients with Laron Syndrome -- Diagnosis of Laron Syndrome -- Genetic Aspects -- Clinical Evaluation -- Perinatal Evaluation -- Perinatal Development ;Laron Syndrome -- Linear Growth Pattern of Untreated Laron Syndrome Patients -- Head Shape, Size and Growth of Untreated Patients with Laron Syndrome -- Sexual Development in Patients with Laron Syndrome.
  note: edited by Zvi Laron, J. Kopchick.
  subject:
    topic: Medicine
  subject:
    topic: Human genetics
  subject:
    topic: Human physiology
  subject:
    topic: Molecular biology
  subject:
    topic: Internal medicine
  subject:
    topic: Endocrinology
  subject:
    topic: Pediatrics
  subject:
    topic: Medicine & Public Health
  subject:
    topic: Pediatrics
  subject:
    topic: Endocrinology
  subject:
    topic: Internal Medicine
  subject:
    topic: Human Genetics
  subject:
    topic: Molecular Medicine
  subject:
    topic: Human Physiology
  classification: RJ1-570
  classification: 618.92
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783642111839
  identifier: http://dx.doi.org/10.1007/978-3-642-11183-9
  record info:
    record creation date: 101125
    record change date: 20151125151215.0
    record identifier: 978-3-642-11183-9