rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Epigenetics and Human Reproduction
  name:
    name part: Rousseaux, Sophie.
    role:
      role term: editor.
  name:
    name part: Khochbin, Saadi.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 372 p. online resource.
  abstract: Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction. The book presents epigenetic transitions that are important at defined stages of gametogenesis and during meiosis. Several of the sixteen chapters written by experts in the field cover fundamental concepts discovered through cellular and biochemical work and from research on animal models. In other chapters, key examples are provided of how disruption of these mechanisms affects germ cell development and fertility, and contributes to the germinal cancers. Finally, the book discusses how in vitro manipulation and culture in assisted reproduction can epigenetically perturb germ cells, and how this can trigger disease phenotypes in the next generation. Conceived towards advanced students, medical professionals and research scientists, this is the first comprehensive textbook on this topic that will serve as a valuable reference during the years to come.
  table of contents: Preface – B. Jegou -- Part 1 - Medical aspects and questions raised on the molecular basis of epigenome involvement in reproduction -- Part 2 - Fundamental aspects of genome and epigenome reprogramming during gametogenesis -- Part 3 – Re-organization of nuclear compartments during gametogenesis -- Part 4 - Fundamental aspects of gene expression regulation during gametogenesis -- Subject index.
  note: edited by Sophie Rousseaux, Saadi Khochbin.
  subject:
    topic: Medicine
  subject:
    topic: Human genetics
  subject:
    topic: Reproductive medicine
  subject:
    topic: Biomedicine
  subject:
    topic: Human Genetics
  subject:
    topic: Reproductive Medicine
  classification: RB155-155.8
  classification: QH431
  classification: 611.01816
  classification: 599.935
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Epigenetics and Human Health
  identifier: 9783642147739
  identifier: http://dx.doi.org/10.1007/978-3-642-14773-9
  record info:
    record creation date: 101109
    record change date: 20151125231747.0
    record identifier: 978-3-642-14773-9