rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Copper-Catalyzed Multi-Component Reactions
    sub title: Synthesis of Nitrogen-Containing Polycyclic Compounds
  name:
    name part: Ohta, Yusuke.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 104 p. online resource.
  abstract: A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.
  note: by Yusuke Ohta.
  subject:
    topic: Chemistry
  subject:
    topic: Organic chemistry
  subject:
    topic: Medicinal chemistry
  subject:
    topic: Chemistry
  subject:
    topic: Organic Chemistry
  subject:
    topic: Medicinal Chemistry
  classification: QD415-436
  classification: 547
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Springer Theses
  identifier: 9783642154737
  identifier: http://dx.doi.org/10.1007/978-3-642-15473-7
  record info:
    record creation date: 110119
    record change date: 20151204185553.0
    record identifier: 978-3-642-15473-7