rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: NF-kB in Health and Disease
  name:
    name part: Karin, Michael.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 268 p. online resource.
  abstract: This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system.
  table of contents: Preface -- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms -- IKK regulation and human genetics -- Specialized chromatin patterns in the control of inflammatory gene expression -- Macrophages and NF-kappaB in Cancer -- NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster -- IKK and NF-kappaB mediated functions in carcinogenesis -- Control of NF-kappaB activity by proteolysis -- NF-kappaB as a target for oncogenic viruses -- NF-kappaB and Innate Immunity -- Inhibition of NF-kappaB signaling as a strategy in disease therapy -- NF-κB and mucosal homeostasis -- NF-kappaB In liver cancer – the plot thickens -- Subject index.
  note: edited by Michael Karin.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Current Topics in Microbiology and Immunology, 349
  identifier: 9783642160172
  identifier: http://dx.doi.org/10.1007/978-3-642-16017-2
  record info:
    record creation date: 110426
    record change date: 20151125211146.0
    record identifier: 978-3-642-16017-2