rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Extracellular Matrix Degradation
  name:
    name part: Parks, William C.
    role:
      role term: editor.
  name:
    name part: Mecham, Robert P.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: X, 255 p. online resource.
  abstract: Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
  table of contents: Matrix Metalloproteinases and Their Inhibitors in Turnover and Degradation of Extracellular Matrix -- Role of Cysteine Cathepsins in Extracellular Proteolysis -- Cooperation between proteolysis and endocytosis in collagen turnover -- Pericellular Proteolysis -- Triple Helicase Activity and the Structural Basis of Collagenolysis -- Structural Basis of Extracellular Matrix Interactions with Matrix Metalloproteinases -- The Role of Matrix Metalloproteinases in Cellular Invasion and Metastasis -- Degradation of bone and the role of osteoclasts, bone lining cells and osteocytes -- Consequences of Elastolysis.
  note: edited by William C. Parks, Robert P. Mecham.
  subject:
    topic: Life sciences
  subject:
    topic: Molecular biology
  subject:
    topic: Biochemistry
  subject:
    topic: Proteins
  subject:
    topic: Cell biology
  subject:
    topic: Life Sciences
  subject:
    topic: Cell Biology
  subject:
    topic: Biochemistry, general
  subject:
    topic: Protein Science
  subject:
    topic: Molecular Medicine
  classification: QH573-671
  classification: 571.6
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Biology of Extracellular Matrix ; 2
  identifier: 9783642168611
  identifier: http://dx.doi.org/10.1007/978-3-642-16861-1
  record info:
    record creation date: 110407
    record change date: 20151030061026.0
    record identifier: 978-3-642-16861-1