rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Targeting Functional Centers of the Ribosome
  name:
    name part: Davidovich, Chen.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIV, 74 p. online resource.
  abstract: This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
  table of contents: Introduction -- Methods -- Results -- Discussion.
  note: by Chen Davidovich.
  subject:
    topic: Life sciences
  subject:
    topic: Organic chemistry
  subject:
    topic: Nucleic acids
  subject:
    topic: Proteins
  subject:
    topic: Life Sciences
  subject:
    topic: Nucleic Acid Chemistry
  subject:
    topic: Protein Science
  subject:
    topic: Organic Chemistry
  classification: QD433-436
  classification: 572.84
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Springer Theses
  identifier: 9783642169311
  identifier: http://dx.doi.org/10.1007/978-3-642-16931-1
  record info:
    record creation date: 110201
    record change date: 20151204182212.0
    record identifier: 978-3-642-16931-1