rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System
  name:
    name part: Slominski, Andrzej T.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Zmijewski, Michal A.
    role:
      role term: author.
  name:
    name part: Skobowiat, Cezary.
    role:
      role term: author.
  name:
    name part: Zbytek, Blazej.
    role:
      role term: author.
  name:
    name part: Slominski, Radomir M.
    role:
      role term: author.
  name:
    name part: Steketee, Jeffery D.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 115 p. 23 illus., 17 illus. in color. online resource.
  abstract: The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-δ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain …
  table of contents: Introduction -- Biogenic amines in the skin -- Melatoninergic system in the skin -- Cutaneous cholinergic system -- Corticotropin signaling system in the skin -- Steroidogenesis in the skin -- Equivalent of hypothalamo-pituitary adrenal axis in the skin -- Cutaneous secosteroidal system -- Equivalent of hypthalamic-pituitary-thyroid axis -- Cutaneous opioid system -- Cutaneous endocannabinoid system -- Perspectives -- References -- Subject index.
  note: by Andrzej T. Slominski, Michal A. Zmijewski, Cezary Skobowiat, Blazej Zbytek, Radomir M. Slominski, Jeffery D. Steketee.
  subject:
    topic: Medicine
  subject:
    topic: Neurosciences
  subject:
    topic: Dermatology
  subject:
    topic: Biomedicine
  subject:
    topic: Neurosciences
  subject:
    topic: Dermatology
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Advances in Anatomy, Embryology and Cell Biology, 212
  identifier: 9783642196836
  identifier: http://dx.doi.org/10.1007/978-3-642-19683-6
  record info:
    record creation date: 120601
    record change date: 20150520195911.0
    record identifier: 978-3-642-19683-6