rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Theory of Phase Transitions in Polypeptides and Proteins
  name:
    name part: Yakubovich, Alexander V.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIII, 121 p. 39 illus., 11 illus. in color. online resource.
  abstract: There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics. The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes.
  table of contents: Introduction -- Theoretical Methods of Quantum Mechanics -- Degrees of Freedom in Polypeptides and Proteins -- Partition Function of a Polypeptide -- Phase Transitions in Polypeptides -- Folding of Proteins in Aqueous Environment.
  note: by Alexander V. Yakubovich.
  subject:
    topic: Physics
  subject:
    topic: Polymers
  subject:
    topic: Proteins
  subject:
    topic: Phase transitions (Statistical physics)
  subject:
    topic: Biophysics
  subject:
    topic: Biological physics
  subject:
    topic: Physics
  subject:
    topic: Biophysics and Biological Physics
  subject:
    topic: Protein Structure
  subject:
    topic: Phase Transitions and Multiphase Systems
  subject:
    topic: Polymer Sciences
  subject:
    topic: Mathematical Methods in Physics
  classification: QH505
  classification: 571.4
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Springer Theses
  identifier: 9783642225925
  identifier: http://dx.doi.org/10.1007/978-3-642-22592-5
  record info:
    record creation date: 110831
    record change date: 20151204165348.0
    record identifier: 978-3-642-22592-5