rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Heteroaromatic Lipoxin A4 Analogues
    sub title: Synthesis and Biological Evaluation
  name:
    name part: Duffy, Colm.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXII, 130 p. online resource.
  abstract: In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
  table of contents: Introduction -- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues -- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues -- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues -- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines -- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues.
  note: by Colm Duffy.
  subject:
    topic: Chemistry
  subject:
    topic: Bioorganic chemistry
  subject:
    topic: Medicinal chemistry
  subject:
    topic: Catalysis
  subject:
    topic: Biochemistry
  subject:
    topic: Chemistry
  subject:
    topic: Bioorganic Chemistry
  subject:
    topic: Biochemistry, general
  subject:
    topic: Medicinal Chemistry
  subject:
    topic: Catalysis
  classification: QD241-441
  classification: 547
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Springer Theses
  identifier: 9783642246326
  identifier: http://dx.doi.org/10.1007/978-3-642-24632-6
  record info:
    record creation date: 120109
    record change date: 20151204145702.0
    record identifier: 978-3-642-24632-6