rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Metallocorroles for Attenuation of Atherosclerosis
  name:
    name part: Haber, Adi.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XX, 88 p. online resource.
  abstract: Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atherosclerosis. There is a focus on both the "bad" and "good" cholesterol carriers, LDL and HDL. Adi Haber proceeds from basic findings in pure chemistry through biochemical and cell culture tests to in vivo examinations. The work in this thesis shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases.
  table of contents: Biologically relevant ROS/RNS -- Atherosclerosis -- The pro-atherogenic role of LDL and macrophages -- The anti-atheroginicity of HDL -- Common treatments for atherosclerosis -- Corroles -- Catalytic antioxidants -- Electronic spectra -- Research Goals -- Results -- Interactions of corroles with lipoproteins -- Corrole-lipoproteins binding -- Corrole distribution in serum -- Spectral changes in the presence of lipoprotein components -- The effect of corroles on oxidative-stress-induced lipoprotein damage -- Cu+2-induced oxidation -- Peroxynitrite-induced oxidation -- Lipoprotein function -- Interactions of corroles with macrophages -- Fluorescence-based detection of 1-Ga -- Chemiluminescence-based detection of 1-Fe -- Cellular accumulation of 1-Fe versus iron(III) porphyrins -- The effect of corroles on macrophage atherogenicity -- Effect on oxidative-stress-induced cell death -- Effect on macrophages cholesterol metabolism.-The effect of corroles on the development of atherosclerosis -- Discussion -- Interaction of corroles with lipoproteins -- Corrole distribution in serum -- Mode of 1-Fe binding to lipoproteins -- Materials and Methods.
  note: by Adi Haber.
  subject:
    topic: Chemistry
  subject:
    topic: Organometallic chemistry
  subject:
    topic: Biochemistry
  subject:
    topic: Chemistry
  subject:
    topic: Organometallic Chemistry
  subject:
    topic: Biochemistry, general
  subject:
    topic: Biomedicine general
  classification: QD410-412.5
  classification: 547.05
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Springer Theses, Recognizing Outstanding Ph.D. Research
  identifier: 9783642303289
  identifier: http://dx.doi.org/10.1007/978-3-642-30328-9
  record info:
    record creation date: 120529
    record change date: 20151204161621.0
    record identifier: 978-3-642-30328-9