rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Prokaryotic Toxin-Antitoxins
  name:
    name part: Gerdes, Kenn.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 368 p. online resource.
  abstract: Prokaryotic Toxins – Antitoxins presents the first comprehensive overview of an exciting and rapidly expanding research field. Toxin – antitoxin (TA) genes were first identified on plasmids almost 30 years ago. Since then it has become evident that TA genes are highly abundant on both plasmids and chromosomes belonging to the bacterial and archaeal domains. TA genes come in three variants, depending on how the antitoxin works. In the most common TA genes, called type II TA loci, the antitoxins are proteins that combine with and neutralize the toxins. Even though the toxins come from at least 10 evolutionary independent gene families they inhibit translation and induce dormancy and persistence. The toxins inhibit translation using different molecular mechanisms. For example, the most common toxin family, called VapC (Virulence-associated protein), inhibits translation by cleaving initiator tRNA. Another common toxin family, called RelE, inhibits translation by cleaving messenger RNA positioned at the ribosome. Recent database mining revealed more than 10,000 such TA loci in »700 prokaryotic organisms. Remarkably, in some species, TA genes have undergone dramatic expansions. For example, the highly persistent major human pathogen Mycobacterium tuberculosis has almost 100 TA loci belonging to different gene families, whereas its close relative M. leprae has none. All sequenced archaeal genomes to date have at least two TA loci and the thermophilic archaeon Sulfolobus tokodaii has »40 TA loci. The considerable expansion of the TA genes is a biological mystery but may be related to the biological function(s) of TA genes, a topic that is still hotly debated. The genetic analysis of TA genes is hampered by the multitude of seemingly similar genes within one particular genome. However, recent analysis with the model organism E. coli revealed a breakthrough indicating that TA genes contribute cumulatively to bacterial persistence. All known free-living bacteria that form per…
  table of contents: Introduction -- Type I Toxin – Antitoxin Systems: Hok/Sok and Fst -- Novel Type I Toxin – Antitoxin Systems -- Type II TA Loci: The Ccdab and Parde Families -- Type II TA Loci: The Relbe Family -- Type II TA Loci: The Unusual Mqsra Locus -- Type II TA Loci: The Mazef Family -- Type II TA Loci: Vapbc and Other TA Loci In Mycobacteria -- Type II TA Loci: Phd Doc Family -- Type II TA Loci: The Fic Family -- Type II TA Loci, Hipab And Persisters -- Type II TA Loci: Zeta/Pezt Family -- Type II Loci: Phylogeny -- Type III TA Loci -- TA Loci Encoded By Plasmids -- TA Loci in Archaea -- TA Loci in Mycobacterium Tuberculosis -- TA Loci in Streptococcus Pneumoniae -- Biotechnological and Medical Exploitations Of TA Genes and Their Components.
  note: edited by Kenn Gerdes.
  subject:
    topic: Life sciences
  subject:
    topic: Medical microbiology
  subject:
    topic: Microbiology
  subject:
    topic: Apoptosis
  subject:
    topic: Microbial genetics
  subject:
    topic: Microbial genomics
  subject:
    topic: Life Sciences
  subject:
    topic: Microbiology
  subject:
    topic: Microbial Genetics and Genomics
  subject:
    topic: Medical Microbiology
  subject:
    topic: Apoptosis
  subject:
    topic: Applied Microbiology
  classification: QR1-502
  classification: 579
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783642332531
  identifier: http://dx.doi.org/10.1007/978-3-642-33253-1
  record info:
    record creation date: 121026
    record change date: 20151125231015.0
    record identifier: 978-3-642-33253-1