rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Intrinsic Immunity
  name:
    name part: Cullen, Bryan R.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VII, 262 p. online resource.
  abstract: Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted. .
  table of contents: The APOBEC3 Family of Retroelement Restriction Factors -- Inhibition of Retroviral Replication by Members of the TRIM Protein Family -- The Antiviral Activities of Tetherin -- Restriction of Retroviral Infection of Macrophages -- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates -- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses -- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response.
  note: edited by Bryan R. Cullen.
  subject:
    topic: Medicine
  subject:
    topic: Immunology
  subject:
    topic: Molecular biology
  subject:
    topic: Virology
  subject:
    topic: Microbial genetics
  subject:
    topic: Microbial genomics
  subject:
    topic: Plant pathology
  subject:
    topic: Invertebrates
  subject:
    topic: Biomedicine
  subject:
    topic: Immunology
  subject:
    topic: Virology
  subject:
    topic: Microbial Genetics and Genomics
  subject:
    topic: Molecular Medicine
  subject:
    topic: Plant Pathology
  subject:
    topic: Invertebrates
  classification: QR180-189.5
  classification: 616.079
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Current Topics in Microbiology and Immunology, 371
  identifier: 9783642377655
  identifier: http://dx.doi.org/10.1007/978-3-642-37765-5
  record info:
    record creation date: 130518
    record change date: 20151125222146.0
    record identifier: 978-3-642-37765-5